Does GVHD make amateurs out of professional APCs?

PU.1 regulates cathepsin S expression in professional APCs.

Cathepsin S (CTSS) is a cysteine protease that is constitutively expressed in APCs and mediates processing of MHC class II-associated invariant chain. CTSS and the Ets family transcription factor PU.1 are highly expressed in cells of both myeloid (macrophages and dendritic cells) and lymphoid (B lymphocytes) lineages. Therefore, we hypothesized that PU.1 participates in the transcriptional regu...

What Difference Does It Make? Evaluating the Impact of Continuing Professional Development in Schools

This article outlines the findings from a recent research study that explored the ways in which continuing professional development is being evaluated in schools. It focuses upon the extent to which schools are gauging the impact of continuing professional development (CPD) particularly at the classroom level. The article provides a contemporary overview of evaluative practice of CPD and conclu...

Thinking out of the box--new approaches to controlling GVHD.

Graft-versus-host disease (GVHD) remains a major limitation of allogeneic hematopoietic cell transplantation (allo-HCT). Despite major advances in the understanding of GVHD pathogenesis, standard GVHD prophylaxis regimens continue to be based on the combination of a calcineurin inhibitor with an antimetabolite, while first line treatments still rely on high-dose corticosteroids. Further, no sec...

Bringing out the DCs' softer side in GVHD.

Turbulence for (and By) Amateurs

4. Series of lectures on statistical turbulence written for amateurs but not experts. Elementary aspects and problems of turbulence in two and three dimensional Navier-Stokes equation are introduced. A few properties of scalar turbulence and transport phenomena in turbulent flows are described. Kraichnan’s model of passive advection is discussed a bit more precisely. Part 1: Approaching turbule...